{"id":443332,"date":"2020-07-08T12:37:16","date_gmt":"2020-07-08T16:37:16","guid":{"rendered":"http:\/\/www.rochester.edu\/newscenter\/?p=443332"},"modified":"2020-07-13T14:51:16","modified_gmt":"2020-07-13T18:51:16","slug":"bats-offer-clues-to-treating-covid-19-443332","status":"publish","type":"post","link":"https:\/\/www.rochester.edu\/newscenter\/bats-offer-clues-to-treating-covid-19-443332\/","title":{"rendered":"Bats offer clues to treating COVID-19"},"content":{"rendered":"
To combat COVID-19, we need to regulate our immune systems to resemble those of bats.<\/div>\n

Bats are often considered patient zero for many deadly viruses affecting humans, including Ebola, rabies, and, most recently, the SARS-CoV-2 strain of virus that causes coronavirus.<\/p>\n

Although humans experience adverse symptoms when afflicted with these pathogens, bats are remarkably able to tolerate viruses, and, additionally, live much longer than similar-sized land mammals.<\/p>\n

What are the secrets to their longevity and virus resistance?<\/p>\n

According to researchers at the Ä¢¹½´«Ã½<\/a>, bats\u2019 longevity and capacity to tolerate viruses may stem from their ability to control inflammation, which is a hallmark of disease and aging. In a review article<\/a> published in the journal Cell Metabolism<\/em>, the researchers\u2014including Rochester biology professors Vera Gorbunova<\/a>\u00a0and\u00a0Andrei Seluanov<\/a>\u2014outline the mechanisms underlying bats\u2019 unique abilities and how these mechanisms may hold clues to developing new treatments for diseases in humans.<\/p>\n

Why are bats \u2018immune\u2019 to viruses?<\/strong><\/h4>\n

The idea for the paper came about when Gorbunova and Seluanov, who are married, were in Singapore in March before COVID-19 travel bans began. When the virus started to spread and Singapore went into lockdown, they were quarantined at the home of their colleague Brian Kennedy, director of the Centre for Healthy Aging<\/a> at the National University of Singapore and co-author of the paper.<\/p>\n

The three scientists, all experts on longevity in mammals, got to talking about bats. SARS-CoV-2 is believed to have originated in bats before the virus was transmitted to humans. Although bats were carriers, they seemed to be unaffected by the virus. Another perplexing factor: generally, a species\u2019 lifespan correlates with its body mass; the smaller a species, the shorter its lifespan, and vice versa. Many bat species, however, have lifespans of 30 to 40 years, which is impressive for their size.<\/p>\n

\u201cWe\u2019ve been interested in longevity and disease resistance in bats for a while, but we didn\u2019t have the time to sit and think about it,\u201d says Gorbunova, the Doris Johns Cherry Professor of Biology at Rochester. \u201cBeing in quarantine gave us time to discuss this, and we realized there may be a very strong connection between bats\u2019 resistance to infectious diseases and their longevity. We also realized that bats can provide clues to human therapies used to fight diseases.\u201d<\/p>\n

While there have been studies on the immune responses of bats and studies of bats\u2019 longevity, until their article, \u201cno one has combined these two phenomena,\u201d Seluanov says.<\/p>\n

Gorbunova and Seluanov have studied longevity and disease resistance<\/a> in other exceptionally long-lived animals, including naked mole rats<\/a>. One common theme in their research is that inflammation is a hallmark of the aging process and age-related diseases, including cancer, Alzheimer\u2019s, and cardiovascular disease. Viruses, including COVID-19, are one factor that can trigger inflammation.<\/p>\n

\u201cWith COVID-19, the inflammation goes haywire, and it may be the inflammatory response that is killing the patient, more so than the virus itself,\u201d Gorbunova says. \u201cThe human immune system works like that: once we get infected, our body sounds an alarm and we develop a fever and inflammation. The goal is to kill the virus and fight infection, but it can also be a detrimental response as our bodies overreact to the threat.\u201d<\/p>\n

Not so with bats. Unlike humans, bats have developed specific mechanisms that reduce viral replication and also dampen the immune response to a virus. The result is a beneficial balance: their immune systems control viruses but at the same time, do not mount a strong inflammatory response.<\/p>\n

Why did bats acquire a tolerance for diseases?<\/strong><\/h4>\n

According to the researchers, there are several factors that may contribute to bats having evolved to fight viruses and live long lives. One factor may be driven by flight. Bats are the only mammals with the ability to fly, which requires that they adapt to rapid increases in body temperature, sudden surges in metabolism, and molecular damage. These adaptations may also assist in disease resistance.<\/p>\n

Another factor may be their environment. Many species of bats live in large, dense colonies, and hang close together on cave ceilings or in trees. Those conditions are ideal for transmitting viruses and other pathogens.<\/p>\n

\u201cBats are constantly exposed to viruses,\u201d Seluanov says. \u201cThey are always flying out and bringing back something new to the cave or nest, and they transfer the virus because they live in such close proximity to each other.\u201d<\/p>\n

Because bats are constantly exposed to viruses, their immune systems are in a perpetual arms race with pathogens: a pathogen will enter the organism, the immune system will evolve a mechanism to combat the pathogen, the pathogen will evolve again, and so on.<\/p>\n

\u201cUsually the strongest driver of new traits in evolution is an arms race with pathogens,\u201d Gorbunova says. \u201cDealing with all of these viruses may be shaping bats\u2019 immunity and longevity.\u201d<\/p>\n

Can humans develop the same disease resistance as bats?<\/strong><\/h4>\n

That\u2019s not an invitation for humans to toss their masks and crowd together in restaurants and movie theaters. Evolution takes place over thousands of years, rather than a few months. It has only been in recent history that a majority of the human population has begun living in close proximity in cities. Or that technology has enabled rapid mobility and travel across continents and around the globe. While humans may be developing social habits that parallel those of bats, we have not yet evolved bats\u2019 sophisticated mechanisms to combat viruses as they emerge and swiftly spread.<\/p>\n

\u201cThe consequences may be that our bodies experience more inflammation,\u201d Gorbunova says.<\/p>\n

The researchers also recognize that aging\u00a0seems to play an adverse role in humans\u2019 reactions to COVID-19.<\/p>\n

\u201cCOVID-19 has such a different pathogenesis in older people,\u201d Gorbunova says. \u201cAge is one of the most critical factors between living and dying. We have to treat aging as a whole process instead of just treating individual symptoms.\u201d<\/p>\n

The researchers anticipate that studying bats\u2019 immune systems will provide new targets for human therapies to fight diseases and aging. For example, bats have mutated or completely eliminated several genes involved in inflammation; scientists can develop drugs to inhibit these genes in humans. Gorbunova and Seluanov hope to start a new research program at Rochester to work toward that goal.<\/p>\n

\u201cHumans have two possible strategies if we want to prevent inflammation, live longer, and avoid the deadly effects of diseases like COVID-19,\u201d Gorbunova says. \u201cOne would be to not be exposed to any viruses, but that\u2019s not practical. The second would be to regulate our immune system more like a bat.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

Bats carry many viruses, including the one behind COVID-19, without becoming ill. Ä¢¹½´«Ã½ biologists are studying the immune system of bats to find potential ways to “mimic” that system in humans. <\/p>\n","protected":false},"author":912,"featured_media":443362,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[116],"tags":[13942,10916,37592,18722,29502,16072,10906],"class_list":["post-443332","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sci-tech","tag-aging","tag-andrei-seluanov","tag-covid-19","tag-department-of-biology","tag-featured-post-side","tag-school-of-arts-and-sciences","tag-vera-gorbunova"],"acf":[],"yoast_head":"\nBats offer clues to treating COVID-19<\/title>\n<meta name=\"description\" content=\"Ä¢¹½´«Ã½ biologists are studying the immune system of bats in the search of potential treatments for COVID-19.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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