{"id":429922,"date":"2020-04-30T17:42:29","date_gmt":"2020-04-30T21:42:29","guid":{"rendered":"http:\/\/www.rochester.edu\/newscenter\/?p=429922"},"modified":"2025-11-19T07:59:38","modified_gmt":"2025-11-19T12:59:38","slug":"remdesivir-promising-rochester-clinical-trial-429922","status":"publish","type":"post","link":"https:\/\/www.rochester.edu\/newscenter\/remdesivir-promising-rochester-clinical-trial-429922\/","title":{"rendered":"Remdesivir results \u2018promising\u2019 in Medical Center clinical trial"},"content":{"rendered":"

The Ä¢¹½´«Ã½<\/a> Medical Center has been participating in a clinical trial<\/a> testing the safety and efficacy of the antiviral drug remdesivir. According to preliminary results<\/a> released by the National Institutes of Health, the drug is now showing promise in treating adults diagnosed with COVID-19.\u00a0<\/span><\/p>\n

\n

Coronavirus update<\/h2>\n

The University\u2019s website<\/a> is a way to find guidance and critical information during a rapidly changing situation.<\/p>\n

COVID-19 symptoms or exposure?<\/h2>\n

Find out what to do <\/a>if you or a close contact have symptoms or think you may have been exposed.<\/p>\n<\/div>\n

The study is led by Ann Falsey<\/a>, a professor in the Department of Medicine (Infectious Diseases), and Angela Branche<\/a>, an assistant professor in the Department of Medicine (Infectious Diseases), with the Medical Center\u2019s Vaccine Treatment and Evaluation Unit (VTEU).\u00a0The Medical Center<\/a> is one of only nine VTEU sites in the US.<\/p>\n

\u201cBased on some of the data that has come out in the last couple of days, it seems that remdesivir does show some proven benefit over placebo,\u201d Branche says.<\/p>\n

Preliminary data from the trials indicate remdesivir speeds up recovery time for some patients with COVID-19. Specifically, the data show that patients who received remdesivir recovered, on average, four days faster than patients who received a placebo (11 days versus 14 days). The results also suggested a mortality rate of 8.0 percent for the group receiving remdesivir versus 11.6 percent for those in the placebo group. That result is considered promising but not statistically significant.<\/p>\n

When Branche and Falsey told their teams about these preliminary results, \u201cone of our nurses said she\u2019s going to go home happy crying instead of sad crying, which I think is reflective of the magnitude of what we\u2019ve been seeing over the past months and how reassuring and rewarding it is to know we are part of something that could be beneficial to people,\u201d Branche says.<\/p>\n

Sixteen COVID-19-positive volunteers from the University\u2019s Strong Memorial Hospital were enrolled in the double-blind, placebo-controlled trial<\/a> and received either placebo or the drug, administered intravenously.\u00a0<\/span><\/p>\n

The trial is ongoing and more information will be forthcoming, including how best to use the drug and whether its effectiveness can be improved by administering it in conjunction with other drugs, such as the anti-inflammatory baricitinib.<\/p>\n

\u201cThe results with remdesivir are positive, but it\u2019s not a miracle drug,\u201d Falsey says. \u201cIt becomes our building block on which we try to improve.\u201d<\/p>\n

Remdesivir, developed by Gilead Sciences, is a broad-spectrum antiviral treatment that has been previously tested in humans with the Ebola virus and has shown promise in animal models for treating Middle East respiratory syndrome\u00a0(MERS) and severe acute respiratory syndrome (SARS), which are caused by other coronaviruses.\u00a0<\/span><\/p>\n

The Medical Center\u2019s VTEU was established with support from the National Institute of Allergy and Infectious Diseases to conduct clinical trials of vaccines, treatments, and diagnostics for known and emergent infectious threats.<\/p>\n","protected":false},"excerpt":{"rendered":"

The Medical Center’s Ann Falsey and Angela Branche, both with the Vaccine and Treatment and Evaluation Unit, are leading an NIH-sponsored clinical trial of remdesivir in the treatment of COVID-19.<\/p>\n","protected":false},"author":912,"featured_media":429952,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[42472,116],"tags":[20232],"class_list":["post-429922","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-medicine","category-sci-tech","tag-ann-falsey"],"acf":[],"yoast_head":"\nRemdesivir results \u2018promising\u2019 in Medical Center clinical trial<\/title>\n<meta name=\"description\" content=\"The Ä¢¹½´«Ã½ Medical Center has been participating in an NIH-sponsored clinical trial of remdesivir in the treatment of COVID-19.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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