{"id":312062,"date":"2018-04-16T11:46:47","date_gmt":"2018-04-16T15:46:47","guid":{"rendered":"http:\/\/www.rochester.edu\/newscenter\/?p=312062"},"modified":"2018-04-16T11:48:09","modified_gmt":"2018-04-16T15:48:09","slug":"university-remembers-andrew-kende-professor-emeritus-of-chemistry-312062","status":"publish","type":"post","link":"https:\/\/www.rochester.edu\/newscenter\/university-remembers-andrew-kende-professor-emeritus-of-chemistry-312062\/","title":{"rendered":"University remembers Andrew Kende, professor emeritus of chemistry"},"content":{"rendered":"

Lanny Liebeskind \u201977 (PhD) remembers walking into Andrew Kende\u2019s lab for the first time as a new PhD student.<\/p>\n

\u201cI remember asking Andy when I should start my research. His succinct answer, in effect, was \u2018Now!\u2019\u201d says Liebeskind, the vice provost for strategic research initiatives and Samuel Dobbs Professor of Chemistry at Emory University.<\/p>\n

University flags will be lowered on April 19 in remembrance of Kende, the Charles F. Houghton Professor of Chemistry, Emeritus, and former chair of chemistry. He was a world renowned organic chemist and inventor who specialized in the synthesis of complex molecules, including ones used for anti-cancer treatments.<\/div>\n

\u201cI got the message loud and clear. It was a bit like being dropped into a professional sports team where the coach is constantly challenging you to push yourself beyond the comfort level. In doing so, you grew in ways as a scholar and person that you never would have on your own.\u201d<\/p>\n

Yuh-geng Tsay \u201977 (PhD) had a similar experience. \u201cWhen I toured Professor Kende\u2019s labs, I noticed there was a memo from him posted in each cubicle of his graduate students and post docs. Two key phrases stood out that got my attention. \u2018When you are here, you should roll up your sleeves and work. If you cannot manage at least two experiments at the same time, you don\u2019t belong to this group.\u2019<\/p>\n

\u201cAt that moment, I knew he would be the professor I wanted to learn from,\u201d says Tsay, a Venture Partner at Vivo Capital, former senior vice president and group president at Thermo Fisher Scientific, and recipient of the University\u2019s Rochester Distinguished Scholar Award<\/a>.<\/p>\n

\u201cI am happiest when faced with a result that is truly counter to the best theories. That is when new insights into the nature of the physical world can be discovered,\u201d Kende said in a University profile.<\/p>\n

\u201cHe was a very astute scientist; he had a really good nose for important problems,\u201d says Robert Boeckman, the Marshall D. Gates Jr. Professor of Chemistry and recent chair of the department, who was recruited to join the faculty by Kende.<\/p>\n

Kende also had a knack for identifying students, such as Liebeskind and Tsay, who had the potential to rise to the tops of their fields \u2013 and for pushing them to excel.<\/p>\n

\u201cHe was a hard taskmaster,\u201d Boeckman says. \u201cBut the vast majority of the more than 50 PhD students and postdocs that Andy mentored went on to perform at the highest levels. \u00a0That\u2019s a testament to how he taught them about the importance of excellence in whatever they do.\u201d<\/p>\n

\u201cThings relate in a sensible way.\u201d<\/strong><\/h3>\n

Born in Budapest, Hungary, Kende emigrated to the United States with his family in 1939, and grew up in Evanston, Ill. He later described being fascinated with chemistry at six years old.<\/p>\n

\u201cIt\u2019s always seemed to me an interesting way to structure information,\u201d he said. \u201cThings relate in a sensible way.\u201d<\/p>\n

At an early age, Kende exemplified the excellence he would later encourage in his students.\u00a0 At 13 he was a Westinghouse Science Talent Search winner; at 16 he enrolled at the University of Chicago, earning a two-year degree. He studied under one Nobel laureate \u2013 Robert Woodward \u2013as a PhD student at Harvard, and under another Nobel laureate \u2013 Derek Barton \u2013 as a postdoc at Glasgow University.<\/p>\n

After college, he worked for 11 years at Lederle Laboratories as a senior research scientist, research associate, and research fellow. Kende played an \u201cinstrumental\u201d role helping the company become the first to synthesize the carbon framework for tetracycline antibiotics, Boeckman says.<\/p>\n

Kende\u2019s discoveries continued after he joined the Ä¢¹½´«Ã½ in 1968.<\/p>\n

For example, he collaborated with Alan Poland, an assistant professor of pharmacology and toxicology, in synthesizing TCDD, a highly toxic, persistent environmental contaminant resulting from the manufacture of herbicides, wood preservatives, and lubricating oils. This was an important first step in setting standards to help regulate TCDD.<\/p>\n

In 1981, Kende and James Rizzi, a graduate student in his lab, were among the first scientists to synthesize aklavinone, which could then be modified as a less expensive, less toxic anti-tumor drug than other treatments then available.<\/p>\n

Several of Kende\u2019s compounds were patented; in 1979 he was chosen inventor of the year by the Rochester Patent Law Association. That same year he was one of 50 U.S. scientists chosen to participate in the nation\u2019s first bilateral scientific symposium with China. Other honors included a Guggenheim Fellowship, the Rochester Section Award of the American Chemical Society, and a Fellowship from the Japanese Society for the Promotion of Science.<\/p>\n

The Department of Chemistry has also created a named professorship in his honor.<\/p>\n

Teaching, research, mentorship, service<\/strong><\/h3>\n

Kende\u2019s passion for chemistry left little time for other interests. \u201cHis routine day started around 11 a.m. and ended about 9 at night,\u201d Boeckman says.<\/p>\n

When Kende wasn\u2019t teaching, doing research, or consulting (for the American Cancer Society, the National Institutes of Health, and for companies such as Dow, Glaxo and Bausch and Lomb), he was doing \u201cservice\u201d — for the field of organic chemistry, for his university, and for his department.<\/p>\n

He served for 12 years as associate editor for Organic Chemistry<\/em> and was a member of the editorial boards of Organic Reactions, Chemical Reviews, Organic Synthesis<\/em> and Synthetic Communications<\/em>. He was a member of University committees for graduate admissions, budget, tenure and privilege, and River Campus parking; he served in the University Senate; he chaired the Scientific Advisory Board of the UR Cancer Center.<\/p>\n

As department chair from 1979 to 1983, he worked with the University\u2019s chief science librarian to introduce chemistry undergraduates to the wonders of the computer as a new way to search for articles and information \u201cburied in the huge and growing body of scientific literature.\u201d This consisted of using an \u201cordinary phone\u201d to dial a database, attaching the receiver to a portable computer terminal, typing in a request, and then \u201cwithin seconds\u201d getting a printout.<\/p>\n

Kende \u201cenjoyed teaching,\u201d Boeckman says, \u201cbut his real thrill was in mentoring and training his graduate students and participating in the research they did.\u201d<\/p>\n

The lessons they learned from him \u2013 about chemistry but also about working hard and achieving excellence \u2013 have remained with them over the years.<\/p>\n

Tsay, for example, remembers that whenever Kende returned from a business trip, \u201che would stop by the lab first to see how everyone was doing. This type of work ethic has inspired us not only to work hard, but to have a sense of urgency in everything you do. His teaching style empowered us to solve any technical challenge and to be independent problem solvers.\u201d<\/p>\n

\u201cArmed with the skills that I learned from him as a graduate student, I was able to excel in every venture that I chose to tackle,\u201d Tsay says. \u201cI was also quite fortunate that Professor Kende agreed to serve as a Scientific Advisor for one of my companies to provide guidance and advice to R&D scientists.\u201d<\/p>\n

\u201cAndy was not a man of many words,\u201d says Liebeskind, who still saves a memo Kende sent to his \u201cgang\u201d of grad students, chastising them for a \u201cslump in productivity.\u201d<\/p>\n

\u201cHe was succinct and to the point. He was clear in his expectations and treated everyone fairly,\u201d Liebeskind says. \u201cHe impressed upon us the purity of the scientific method and the sanctity of data and critical observations married to critical analysis.<\/p>\n

\u201cHe was a perfect mentor for me at that earlier stage of my life and helped me grow and mature into the person and scientist\/scholar that I became.<\/p>\n

\u201cHe is missed.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

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