{"id":3576,"date":"2024-05-17T19:59:13","date_gmt":"2024-05-17T23:59:13","guid":{"rendered":"https:\/\/www.rochester.edu\/college\/ugresearch\/jur\/?page_id=3576"},"modified":"2024-10-12T11:23:18","modified_gmt":"2024-10-12T15:23:18","slug":"xupouhem","status":"publish","type":"page","link":"https:\/\/www.rochester.edu\/college\/ugresearch\/jur\/xupouhem\/","title":{"rendered":"Investigating the Interaction between Macrophages and Erythroid Cells in Bone Marrow: Implications for Erythropoiesis and Anemia"},"content":{"rendered":"<h5 style=\"text-align: justify;\"><b>Abstract<\/b><b>\u00a0<\/b><\/h5>\n<p style=\"text-align: justify;\">Macrophages play a pivotal role in erythropoiesis, the process of red blood cell (RBC) formation, through their involvement in various stages of erythrocyte development. Located in the bone marrow, these macrophages create specialized microenvironments called erythroblastic islands (EBIs) by associating with erythroid cells. (1) Additionally, macrophages may perform different functions in the bone marrow, either by interacting with erythroid cells or with other cell types. Identifying specific markers to classify macrophage subsets could enhance our understanding of their roles in erythropoiesis and blood disorders. This work applied different molecular markers to study the interactions between macrophages and erythroid cells in murine bone marrow using imaging flow cytometry. The results suggest a higher number of erythroid-associated macrophages compared to single macrophages in the bone marrow as well as the potential tendency for macrophages to become \u201cnurse\u201d cells to support the development of erythroid cells in anemia.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract\u00a0 Macrophages play a pivotal role in erythropoiesis, the process of red blood cell (RBC) formation, through their involvement in various stages of erythrocyte development. Located in the bone marrow,&hellip;<\/p>\n","protected":false},"author":26,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/one-column.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3576","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigating the Interaction between Macrophages and Erythroid Cells in Bone Marrow:<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.rochester.edu\/college\/ugresearch\/jur\/xupouhem\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigating the Interaction between Macrophages and Erythroid Cells in Bone Marrow:\" \/>\n<meta property=\"og:description\" content=\"Abstract\u00a0 Macrophages play a pivotal role in erythropoiesis, the process of red blood cell (RBC) formation, through their involvement in various stages of erythrocyte development. Located in the bone marrow,&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.rochester.edu\/college\/ugresearch\/jur\/xupouhem\/\" \/>\n<meta property=\"og:site_name\" content=\"The Journal of Undergraduate Research\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-12T15:23:18+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.rochester.edu\\\/college\\\/ugresearch\\\/jur\\\/xupouhem\\\/\",\"url\":\"https:\\\/\\\/www.rochester.edu\\\/college\\\/ugresearch\\\/jur\\\/xupouhem\\\/\",\"name\":\"Investigating the Interaction between Macrophages and Erythroid Cells in Bone Marrow:\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.rochester.edu\\\/college\\\/ugresearch\\\/jur\\\/#website\"},\"datePublished\":\"2024-05-17T23:59:13+00:00\",\"dateModified\":\"2024-10-12T15:23:18+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.rochester.edu\\\/college\\\/ugresearch\\\/jur\\\/xupouhem\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.rochester.edu\\\/college\\\/ugresearch\\\/jur\\\/xupouhem\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.rochester.edu\\\/college\\\/ugresearch\\\/jur\\\/xupouhem\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.rochester.edu\\\/college\\\/ugresearch\\\/jur\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Investigating the Interaction between Macrophages and Erythroid Cells in Bone Marrow: Implications for Erythropoiesis and Anemia\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.rochester.edu\\\/college\\\/ugresearch\\\/jur\\\/#website\",\"url\":\"https:\\\/\\\/www.rochester.edu\\\/college\\\/ugresearch\\\/jur\\\/\",\"name\":\"The Journal of Undergraduate Research\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.rochester.edu\\\/college\\\/ugresearch\\\/jur\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Investigating the Interaction between Macrophages and Erythroid Cells in Bone Marrow:","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.rochester.edu\/college\/ugresearch\/jur\/xupouhem\/","og_locale":"en_US","og_type":"article","og_title":"Investigating the Interaction between Macrophages and Erythroid Cells in Bone Marrow:","og_description":"Abstract\u00a0 Macrophages play a pivotal role in erythropoiesis, the process of red blood cell (RBC) formation, through their involvement in various stages of erythrocyte development. 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