Factor<\/a> XIII (FXIII), a key clotting factor in the coagulation cascade, reinforces the covalent bonds between fibrin monomers, stabilizes fibrin clots, and protects fibrins from premature fibrinolysis, a process that breaks down fibrin in blood clots. FXIII deficiency, a rare condition that is either congenital or acquired, results in a number of complications, such as impairing clot stability, increasing bleeding tendency, and delaying bleeding episodes.<\/p>\nCase:<\/b><\/h5>\n
A 76-year-old male with a history of Graves\u2019 disease, asthma, hyperlipidemia, and hypertension was presented to the emergency department with exertional fatigue, pain across his left flank, and ecchymosis over his right lateral abdominal wall. The patient reported prior bruising on the left lateral abdominal wall and denied any trauma, new medical conditions, or medications.<\/p>\n
Initial laboratory work-up displayed normal basic coagulation studies and liver function, but decreased kidney function and acute anemia. However, a CT scan of the chest and abdominal region revealed extensive left flank hematoma, fluid attenuation across the right scapula, and hydronephrosis in the kidneys. Further tests observed enlargement of the right paraspinal muscles, evidence for a hematoma.<\/p>\n","protected":false},"excerpt":{"rendered":"
Case Background: Factor XIII (FXIII), a key clotting factor in the coagulation cascade, reinforces the covalent bonds between fibrin monomers, stabilizes fibrin clots, and protects fibrins from premature fibrinolysis, a…<\/p>\n","protected":false},"author":26,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/one-column.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3556","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\n
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