{"id":21602,"date":"2025-08-20T21:29:22","date_gmt":"2025-08-21T01:29:22","guid":{"rendered":"https:\/\/www.rochester.edu\/college\/ugresearch\/jur\/?page_id=21602"},"modified":"2026-03-19T10:34:57","modified_gmt":"2026-03-19T14:34:57","slug":"diurnal-relocalization-of-brevican-in-perineuronal-nets","status":"publish","type":"page","link":"https:\/\/www.rochester.edu\/college\/ugresearch\/jur\/diurnal-relocalization-of-brevican-in-perineuronal-nets\/","title":{"rendered":"Diurnal Relocalization of Brevican in Perineuronal Nets"},"content":{"rendered":"
Abstract<\/h5>\n

Perineuronal Nets (PNNs) are specialized structures of the extracellular matrix (ECM) that localize tightly around specific types of neurons, providing structural support, altering membrane potential, and regulating synaptic transmission. PNNs have been shown to rapidly degrade and reappear in periods of sleep, learning, injury, and reward. Brevican (BCAN) is an important portion of the PNN and has altered levels in a variety of psychiatric diseases, models of traumatic brain injury (TBI), and glioma. However, the exact way PNNs as a whole and
\nBCAN specifically is modulated is a current area of research with no clear answer. This study aims to replicate previous studies showing diurnal rhythms, differences in metabolism, and transcription based on time of day, in PNNs. Along with this, we shed light on whether or not degradation and reappearance of PNNs is a complete breakdown and resynthesis, or simply a relocalization of building blocks from the ECM.<\/p>\n","protected":false},"excerpt":{"rendered":"

Abstract Perineuronal Nets (PNNs) are specialized structures of the extracellular matrix (ECM) that localize tightly around specific types of neurons, providing structural support, altering membrane potential, and regulating synaptic transmission.…<\/p>\n","protected":false},"author":26,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-21602","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nDiurnal Relocalization of Brevican in Perineuronal Nets - The Journal of Undergraduate Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.rochester.edu\/college\/ugresearch\/jur\/diurnal-relocalization-of-brevican-in-perineuronal-nets\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Diurnal Relocalization of Brevican in Perineuronal Nets - 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